6YLC
Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Mitogen-activated protein kinase 6 | polymer | 319 | 36193.7 | 4 | UniProt (Q16659) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 6,Extracellular signal-regulated kinase 3,ERK-3,MAP kinase isoform p97,p97-MAPK |
| 2 | A, B, C, D | 5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile | non-polymer | 418.4 | 4 | Chemie (OXW) | |||
| 3 | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 9 - 327 (UniProt: Q16659)
| PDB | External Database | Details |
|---|---|---|
| Val 290 | Leu 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 144774.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1673.7 | |
| All* | Total formula weight | 146448.4 |
