6YLC

Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors

Summary for 6YLC

Entry DOI	10.2210/pdb6ylc/pdb
Related	6YKY
Descriptor	Mitogen-activated protein kinase 6, 5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile (3 entities in total)
Functional Keywords	human mitogen activated protein kinase 6 (mapk6), erk3, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	146448.41
Authors	Graedler, U. (deposition date: 2020-04-07, release date: 2020-09-23, Last modification date: 2024-01-24)
Primary citation	Gradler, U.,Busch, M.,Leuthner, B.,Raba, M.,Burgdorf, L.,Lehmann, M.,Linde, N.,Esdar, C. Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors. Bioorg.Med.Chem.Lett., 30:127551-127551, 2020 Cited by PubMed: 32927028 DOI: 10.1016/j.bmcl.2020.127551 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation