6YK5

Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A

6YK5 の概要

• エントリーDOI: 10.2210/pdb6yk5/pdb
• 分子名称: Glutamate receptor 2, GLYCEROL, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: ionotropic glutamate receptor, glua2o ligand-binding domain, bicyclic pyrimidinedione analogue, membrane protein
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30507.08

構造登録者

Frydenvang, K.,Kastrup, J.S. (登録日: 2020-04-05, 公開日: 2020-06-03, 最終更新日: 2024-01-24)

• 主引用文献: Frydenvang, K.,Pickering, D.S.,Kshirsagar, G.U.,Chemi, G.,Gemma, S.,Sprogoe, D.,Kærn, A.M.,Brogi, S.,Campiani, G.,Butini, S.,Kastrup, J.S.; Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.; Acs Chem Neurosci, 11:1791-1800, 2020; PubMed: 32437601; DOI: 10.1021/acschemneuro.0c00195

実験手法

X-RAY DIFFRACTION (1.15 Å)