6YIZ

Crystal structure of PqsR (MvfR) ligand-binding domain in complex with triazolo-pyridine inverse agonist A

Summary for 6YIZ

• Entry DOI: 10.2210/pdb6yiz/pdb
• Descriptor: Transcriptional regulator MvfR, 7-oxidanylidene-8-[2-(4-sulfonaphthalen-1-yl)hydrazinyl]-8~{H}-naphthalene-1,3-disulfonic acid, ~{N}-[[1-(4-phenoxyphenyl)-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridin-4-amine, ... (5 entities in total)
• Functional Keywords: quorum sensing, lysr-type transcriptional regulator, pseudomonas, 2 quinolone signaling system, lttr, dna binding protein
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 2
• Total formula weight: 53328.29

Authors

Schmelz, S.,Blankenfeldt, W. (deposition date: 2020-04-01, release date: 2021-04-14, Last modification date: 2024-01-24)

• Primary citation: Schutz, C.,Ho, D.K.,Hamed, M.M.,Abdelsamie, A.S.,Rohrig, T.,Herr, C.,Kany, A.M.,Rox, K.,Schmelz, S.,Siebenburger, L.,Wirth, M.,Borger, C.,Yahiaoui, S.,Bals, R.,Scrima, A.,Blankenfeldt, W.,Horstmann, J.C.,Christmann, R.,Murgia, X.,Koch, M.,Berwanger, A.,Loretz, B.,Hirsch, A.K.H.,Hartmann, R.W.,Lehr, C.M.,Empting, M.; A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.; Adv Sci, 8:e2004369-e2004369, 2021; PubMed: 34165899; DOI: 10.1002/advs.202004369

Experimental method

X-RAY DIFFRACTION (2.163 Å)