6YIL
Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand
Summary for 6YIL
Entry DOI | 10.2210/pdb6yil/pdb |
Descriptor | CREBBP, (3~{R})-~{N}-[3-(3,4-dihydro-2~{H}-quinolin-1-yl)-2,2-bis(fluoranyl)propyl]-3-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoxaline-5-carboxamide (3 entities in total) |
Functional Keywords | bromodomain, crebbp, small molecule, benzo-diazepine, sgc, structural genomics consortium, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14637.80 |
Authors | Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. (deposition date: 2020-04-01, release date: 2020-04-15, Last modification date: 2024-01-24) |
Primary citation | Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.22 Å) |
Structure validation
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