6YI8
HUMAN FGFR4 KINASE DOMAIN (447-753) IN COMPLEX WITH ROBLITINIB
Summary for 6YI8
Entry DOI | 10.2210/pdb6yi8/pdb |
Descriptor | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | tyrosine kinase inhibitor, covalent reversible inhibitor, fgfr4, roblitinib, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70178.74 |
Authors | Ostermann, N. (deposition date: 2020-04-01, release date: 2020-09-30, Last modification date: 2024-10-09) |
Primary citation | Fairhurst, R.A.,Knoepfel, T.,Buschmann, N.,Leblanc, C.,Mah, R.,Todorov, M.,Nimsgern, P.,Ripoche, S.,Niklaus, M.,Warin, N.,Luu, V.H.,Madoerin, M.,Wirth, J.,Graus-Porta, D.,Weiss, A.,Kiffe, M.,Wartmann, M.,Kinyamu-Akunda, J.,Sterker, D.,Stamm, C.,Adler, F.,Buhles, A.,Schadt, H.,Couttet, P.,Blank, J.,Galuba, I.,Trappe, J.,Voshol, J.,Ostermann, N.,Zou, C.,Berghausen, J.,Del Rio Espinola, A.,Jahnke, W.,Furet, P. Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4. J.Med.Chem., 63:12542-12573, 2020 Cited by PubMed: 32930584DOI: 10.1021/acs.jmedchem.0c01019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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