6YHE

tRNA-Guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

6YHE の概要

• エントリーDOI: 10.2210/pdb6yhe/pdb
• 関連するPDBエントリー: 6YGY
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, ... (4 entities in total)
• 機能のキーワード: transferase, tgt, trna-guanine transglycosylase, guanine insertion enzyme, homodimer, 19f nmr
• 由来する生物種: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43637.66

構造登録者

Nguyen, A.,Heine, A.,Klebe, G. (登録日: 2020-03-29, 公開日: 2020-04-08, 最終更新日: 2024-01-24)

• 主引用文献: Nguyen, A.,Heine, A.,Klebe, G.; Co-crystallization, 19F NMR and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts; To Be Published,

実験手法

X-RAY DIFFRACTION (1.54 Å)