6YHD

tRNA-guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-4-(2-((2R,3S,4R,5R)-3,4-dihydroxy-5-methoxytetrahydrofuran-2-yl)ethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 6YHD

• Entry DOI: 10.2210/pdb6yhd/pdb
• Related: 6YGZ 6YH2
• Descriptor: Queuine tRNA-ribosyltransferase, methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-beta-D-ribo-hexofuranoside, GLYCEROL, ... (6 entities in total)
• Functional Keywords: transferase, tgt, trna-guanine transglycosylase, guanine insertion enzyme, homodimer, 19f nmr
• Biological source: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
• Total number of polymer chains: 1
• Total formula weight: 43817.23

Authors

Nguyen, A.,Heine, A.,Klebe, G. (deposition date: 2020-03-28, release date: 2020-04-08, Last modification date: 2024-01-24)

• Primary citation: Nguyen, A.,Heine, A.,Klebe, G.; Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.25 Å)