6YGJ

small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction

6YGJ の概要

• エントリーDOI: 10.2210/pdb6ygj/pdb
• 分子名称: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid, ... (5 entities in total)
• 機能のキーワード: 14-3-3, stabilizer, protein-protein interaction, chrebp, small molecule, structural protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 59136.56

構造登録者

Ottmann, C.,Visser, E.J. (登録日: 2020-03-27, 公開日: 2020-09-16, 最終更新日: 2024-01-24)

• 主引用文献: Sijbesma, E.,Visser, E.,Plitzko, K.,Thiel, P.,Milroy, L.G.,Kaiser, M.,Brunsveld, L.,Ottmann, C.; Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.; Nat Commun, 11:3954-3954, 2020; PubMed: 32770072; DOI: 10.1038/s41467-020-17741-0

実験手法

X-RAY DIFFRACTION (2.07 Å)