6YEF
70S initiation complex with assigned rRNA modifications from Staphylococcus aureus
This is a non-PDB format compatible entry.
Summary for 6YEF
| Entry DOI | 10.2210/pdb6yef/pdb |
| EMDB information | 10791 |
| Descriptor | 16S rRNA, ribosomal protein uS10, 30S ribosomal protein S11, ... (54 entities in total) |
| Functional Keywords | rrna modifications, 70s, initiation complex, s. aureus, ribosome |
| Biological source | Staphylococcus aureus subsp. aureus NCTC 8325 More |
| Total number of polymer chains | 52 |
| Total formula weight | 2181505.10 |
| Authors | Fatkhullin, B.,Golubev, A.,Khusainov, I.,Yusupova, G.,Yusupov, M. (deposition date: 2020-03-24, release date: 2021-01-27, Last modification date: 2025-03-12) |
| Primary citation | Golubev, A.,Fatkhullin, B.,Khusainov, I.,Jenner, L.,Gabdulkhakov, A.,Validov, S.,Yusupova, G.,Yusupov, M.,Usachev, K. Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 angstrom resolution. Febs Lett., 594:3551-3567, 2020 Cited by PubMed Abstract: Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for new drugs and treatments. As the majority of antibiotics target the ribosome, knowledge of its detailed structure is crucial for drug development. Here, we report the cryo-EM reconstruction at 3.2 Å resolution of the S. aureus ribosome with P-site tRNA, messenger RNA, and 10 RNA modification sites previously not assigned or visualized. The resulting model is the most precise and complete high-resolution structure to date of the S. aureus 70S ribosome with functional ligands. PubMed: 32852796DOI: 10.1002/1873-3468.13915 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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