6YD2
X-ray structure of furin in complex with the canavanine-based inhibitor 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba
This is a non-PDB format compatible entry.
Summary for 6YD2
Entry DOI | 10.2210/pdb6yd2/pdb |
Descriptor | Furin, 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba, CALCIUM ION, ... (8 entities in total) |
Functional Keywords | protease, inhibitor, complex, canavanine, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 53578.20 |
Authors | Dahms, S.O. (deposition date: 2020-03-20, release date: 2021-02-17, Last modification date: 2024-01-31) |
Primary citation | Lam van, T.V.,Heindl, M.R.,Schlutt, C.,Bottcher-Friebertshauser, E.,Bartenschlager, R.,Klebe, G.,Brandstetter, H.,Dahms, S.O.,Steinmetzer, T. The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. Acs Med.Chem.Lett., 12:426-432, 2021 Cited by PubMed: 33732412DOI: 10.1021/acsmedchemlett.0c00651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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