6YD2
X-ray structure of furin in complex with the canavanine-based inhibitor 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Furin | polymer | 482 | 52388.6 | 1 | UniProt (P09958) Pfam (PF00082) Pfam (PF01483) In PDB | Homo sapiens (human) | Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE |
2 | 611 | 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba | polymer | 5 | 696.9 | 1 | synthetic construct | ||
3 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
7 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
8 | water | water | 18.0 | 443 | Chemie (HOH) |
Sequence modifications
A: 108 - 574 (UniProt: P09958)
PDB | External Database | Details |
---|---|---|
Ser 575 | - | expression tag |
Gly 576 | - | expression tag |
Ser 577 | - | expression tag |
Leu 578 | - | expression tag |
Val 579 | - | expression tag |
Pro 580 | - | expression tag |
Arg 581 | - | expression tag |
Gly 582 | - | expression tag |
Ser 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
His 586 | - | expression tag |
His 587 | - | expression tag |
His 588 | - | expression tag |
His 589 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 53085.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 492.7 | |
All* | Total formula weight | 53578.2 |