6Y7T

Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding

Summary for 6Y7T

• Entry DOI: 10.2210/pdb6y7t/pdb
• Descriptor: 14-3-3 protein sigma, Exoenzyme S, SODIUM ION, ... (6 entities in total)
• Functional Keywords: protein-protein interactions, supramolecular ligands, molecular tweezers, protein recognition, hybrid ligands, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 117195.25

Authors

Guillory, X.,Ottmann, C. (deposition date: 2020-03-02, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Guillory, X.,Hadrovic, I.,de Vink, P.J.,Sowislok, A.,Brunsveld, L.,Schrader, T.,Ottmann, C.; Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand.; J.Am.Chem.Soc., 143:13495-13500, 2021; PubMed: 34427424; DOI: 10.1021/jacs.1c07095

Experimental method

X-RAY DIFFRACTION (2.5 Å)