6Y5E
Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)
Summary for 6Y5E
Entry DOI | 10.2210/pdb6y5e/pdb |
EMDB information | 10695 11005 11006 |
Descriptor | Histone H3.2, Cyclic GMP-AMP synthase, PENTANEDIAL, ... (12 entities in total) |
Functional Keywords | cgas, sting, nucleosome, innate immunity, cgmp-amp, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 11 |
Total formula weight | 223094.65 |
Authors | Pathare, G.R.,Cavadini, S.,Kempf, G.,Thoma, N.H. (deposition date: 2020-02-25, release date: 2020-09-23, Last modification date: 2020-12-09) |
Primary citation | Pathare, G.R.,Decout, A.,Gluck, S.,Cavadini, S.,Makasheva, K.,Hovius, R.,Kempf, G.,Weiss, J.,Kozicka, Z.,Guey, B.,Melenec, P.,Fierz, B.,Thoma, N.H.,Ablasser, A. Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587:668-672, 2020 Cited by PubMed: 32911482DOI: 10.1038/s41586-020-2750-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.15 Å) |
Structure validation
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