6Y4Q

Structure of a stapled peptide bound to MDM2

6Y4Q の概要

• エントリーDOI: 10.2210/pdb6y4q/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: mdm2, p53, stapled, ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 25377.72

構造登録者

Pantelejevs, T.,Bakanovych, I. (登録日: 2020-02-22, 公開日: 2020-05-20, 最終更新日: 2024-01-24)

• 主引用文献: Strizhak, A.V.,Babii, O.,Afonin, S.,Bakanovich, I.,Pantelejevs, T.,Xu, W.,Fowler, E.,Eapen, R.,Sharma, K.,Platonov, M.O.,Hurmach, V.V.,Itzhaki, L.,Hyvonen, M.,Ulrich, A.S.,Spring, D.R.,Komarov, I.V.; Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.; Org.Biomol.Chem., 18:5359-5369, 2020; PubMed: 32390036; DOI: 10.1039/d0ob00831a

実験手法

X-RAY DIFFRACTION (1.63 Å)