6Y2U

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with aminofasudil and PKI (5-24)

6Y2U の概要

• エントリーDOI: 10.2210/pdb6y2u/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine, ... (4 entities in total)
• 機能のキーワード: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43646.56

構造登録者

Oebbeke, M.,Gerber, H.-D.,Heine, A.,Klebe, G. (登録日: 2020-02-17, 公開日: 2021-03-31, 最終更新日: 2024-01-24)

• 主引用文献: Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G.; Fragment based drug design - Small chemical changes of fragments effecting big changes in binding; To Be Published,

実験手法

X-RAY DIFFRACTION (1.93 Å)