6XY7

Human SHIP1 with magnesium and phosphate bound to the active site

This is a non-PDB format compatible entry.

Summary for 6XY7

• Entry DOI: 10.2210/pdb6xy7/pdb
• Descriptor: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, MAGNESIUM ION, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: phosphatidylinositol, phosphate, phosphatase, alzheimer's disease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 53381.42

Authors

Bradshaw, W.J.,Scacioc, A.,Fernandez-Cid, A.,Mckinley, G.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O. (deposition date: 2020-01-29, release date: 2020-02-26, Last modification date: 2024-02-14)

• Primary citation: Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O.; Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.; Structure, 2024; PubMed: 38309262; DOI: 10.1016/j.str.2024.01.005

Experimental method

X-RAY DIFFRACTION (1.086 Å)