6XXT
The crystal structure of hCA II in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.
Summary for 6XXT
Entry DOI | 10.2210/pdb6xxt/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-[4-(phenylcarbonyl)piperazin-1-yl]carbonylbenzenesulfonamide, ... (5 entities in total) |
Functional Keywords | protein-inhibitor adduct, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 30008.24 |
Authors | Di Fiore, A.,De Simone, G. (deposition date: 2020-01-28, release date: 2020-06-03, Last modification date: 2024-01-24) |
Primary citation | Mancuso, F.,Di Fiore, A.,De Luca, L.,Angeli, A.,Monti, S.M.,De Simone, G.,Supuran, C.T.,Gitto, R. Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms. Acs Med.Chem.Lett., 11:1000-1005, 2020 Cited by PubMed: 32435417DOI: 10.1021/acsmedchemlett.0c00062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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