6XS9

Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-L1

Summary for 6XS9

• Entry DOI: 10.2210/pdb6xs9/pdb
• Related: 6XS5 6XS7 6XS8
• Descriptor: Vacuolar protein sorting-associated protein 29, 48V-TYR-ILE-LYS-THR-PRO-LEU-GLY-THR-PHE-PRO-ASN-ARG-HIS-GLY, MALONATE ION, ... (7 entities in total)
• Functional Keywords: vps29, retromer, endosome, protein transport, cyclic peptide, inhibitor, protein transport-inhibitor complex, protein transport/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 51182.67

Authors

Chen, K.-E.,Guo, Q.,Collins, B.M. (deposition date: 2020-07-15, release date: 2021-07-21, Last modification date: 2023-11-15)

• Primary citation: Chen, K.E.,Guo, Q.,Hill, T.A.,Cui, Y.,Kendall, A.K.,Yang, Z.,Hall, R.J.,Healy, M.D.,Sacharz, J.,Norwood, S.J.,Fonseka, S.,Xie, B.,Reid, R.C.,Leneva, N.,Parton, R.G.,Ghai, R.,Stroud, D.A.,Fairlie, D.P.,Suga, H.,Jackson, L.P.,Teasdale, R.D.,Passioura, T.,Collins, B.M.; De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.; Sci Adv, 7:eabg4007-eabg4007, 2021; PubMed: 34851660; DOI: 10.1126/sciadv.abg4007

Experimental method

X-RAY DIFFRACTION (2.69 Å)