6XM2
The structure of the 4A11.v7 antibody in complex with human TGFb2
Summary for 6XM2
Entry DOI | 10.2210/pdb6xm2/pdb |
Descriptor | 4A11.v7 kappa light chain Fab (VL-CL) humanized, 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, Transforming growth factor beta-2, ... (4 entities in total) |
Functional Keywords | tgfb antibody, cytokine, cytokine-immune system complex, cytokine/immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 12 |
Total formula weight | 243111.78 |
Authors | Lupardus, P.J.,Yin, J.P. (deposition date: 2020-06-29, release date: 2021-07-07, Last modification date: 2023-10-18) |
Primary citation | Sun, T.,Huang, Z.,Liang, W.C.,Yin, J.,Lin, W.Y.,Wu, J.,Vernes, J.M.,Lutman, J.,Caplazi, P.,Jeet, S.,Wong, T.,Wong, M.,DePianto, D.J.,Morshead, K.B.,Sun, K.H.,Modrusan, Z.,Vander Heiden, J.A.,Abbas, A.R.,Zhang, H.,Xu, M.,N'Diaye, E.N.,Roose-Girma, M.,Wolters, P.J.,Yadav, R.,Sukumaran, S.,Ghilardi, N.,Corpuz, R.,Emson, C.,Meng, Y.G.,Ramalingam, T.R.,Lupardus, P.,Brightbill, H.D.,Seshasayee, D.,Wu, Y.,Arron, J.R. TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis. Sci Transl Med, 13:-, 2021 Cited by PubMed: 34349032DOI: 10.1126/scitranslmed.abe0407 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
Download full validation report