6XKR
Structure of Sasanlimab Fab in complex with PD-1
Summary for 6XKR
Entry DOI | 10.2210/pdb6xkr/pdb |
Descriptor | Sasanlimab Fab Heavy chain, Sasanlimab Fab Light chain, Programmed cell death protein 1, ... (5 entities in total) |
Functional Keywords | anti-pd-1, fab, complex, immuno-oncology, antitumor protein, antitumor protein-immune system complex, antitumor protein/immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 65490.76 |
Authors | Kimberlin, C.R.,Chin, S.M. (deposition date: 2020-06-27, release date: 2020-09-09, Last modification date: 2023-10-18) |
Primary citation | Al-Khami, A.A.,Youssef, S.,Abdiche, Y.,Nguyen, H.,Chou, J.,Kimberlin, C.R.,Chin, S.M.,Kamperschroer, C.,Jessen, B.,Kern, B.,Budimir, N.,Dillon, C.P.,Xu, A.,Clark, J.D.,Chou, J.,Kraynov, E.,Rajpal, A.,Lin, J.C.,Salek-Ardakani, S. Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody. Mol.Cancer Ther., 19:2105-2116, 2020 Cited by PubMed: 32847983DOI: 10.1158/1535-7163.MCT-20-0093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
Download full validation report