6XHA

Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF

6XHA の概要

• エントリーDOI: 10.2210/pdb6xha/pdb
• 分子名称: Isoform 2B of GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (8 entities in total)
• 機能のキーワード: kras, ras, k-ras, kras4b, g12v, raf1, craf, rbd, ras-binding domain, cysteine-rich domain, crd, oncoprotein, oncoprotein-transferase complex, oncoprotein/transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36359.87

構造登録者

Tran, T.H.,Chan, A.H.,Dharmaiah, S.,Simanshu, D.K. (登録日: 2020-06-18, 公開日: 2021-01-13, 最終更新日: 2024-04-03)

• 主引用文献: Tran, T.H.,Chan, A.H.,Young, L.C.,Bindu, L.,Neale, C.,Messing, S.,Dharmaiah, S.,Taylor, T.,Denson, J.P.,Esposito, D.,Nissley, D.V.,Stephen, A.G.,McCormick, F.,Simanshu, D.K.; KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.; Nat Commun, 12:1176-1176, 2021; PubMed: 33608534; DOI: 10.1038/s41467-021-21422-x

実験手法

X-RAY DIFFRACTION (2.87 Å)