6XG4
X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
Summary for 6XG4
Entry DOI | 10.2210/pdb6xg4/pdb |
Related | 1dre 1drh 1rh3 7dfr |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (6 entities in total) |
Functional Keywords | dihydrofolate reductase, dhfr, mutant, complex, trimethoprim, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 20055.55 |
Authors | Gaszek, I.K.,Manna, M.S.,Borek, D.,Toprak, E. (deposition date: 2020-06-16, release date: 2021-03-24, Last modification date: 2024-04-03) |
Primary citation | Manna, M.S.,Tamer, Y.T.,Gaszek, I.,Poulides, N.,Ahmed, A.,Wang, X.,Toprak, F.C.R.,Woodard, D.R.,Koh, A.Y.,Williams, N.S.,Borek, D.,Atilgan, A.R.,Hulleman, J.D.,Atilgan, C.,Tambar, U.,Toprak, E. A trimethoprim derivative impedes antibiotic resistance evolution. Nat Commun, 12:2949-2949, 2021 Cited by PubMed: 34011959DOI: 10.1038/s41467-021-23191-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report