6XAF

1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H

6XAF の概要

• エントリーDOI: 10.2210/pdb6xaf/pdb
• 分子名称: Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: parkinson's disease, lrrk2, gtpase, dimer, interswitch, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47686.79

構造登録者

Hoang, Q.Q.,Liao, J.,Huang, X.,Park, Y.,Wu, C.X. (登録日: 2020-06-04, 公開日: 2021-06-09, 最終更新日: 2023-10-18)

• 主引用文献: Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q.; Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2; To be Published,

実験手法

X-RAY DIFFRACTION (1.968 Å)