6X9H

Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)

6X9H の概要

• エントリーDOI: 10.2210/pdb6x9h/pdb
• 分子名称: Acid-sensing ion channel 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1H-benzimidazole-6-carboximidamide, ... (4 entities in total)
• 機能のキーワード: asic1, modulation, membrane protein, transport protein
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 152314.13

構造登録者

Liu, Y.,Ma, J.,DesJarlais, R.L.,Hagan, R.,Rech, J.,Lin, D.,Liu, C.,Miller, R.,Schoellerman, J.,Luo, J.,Letavic, M.,Grasberger, B.,Maher, M. (登録日: 2020-06-02, 公開日: 2020-12-30, 最終更新日: 2023-10-18)

• 主引用文献: Liu, Y.,Ma, J.,DesJarlais, R.L.,Hagan, R.,Rech, J.,Lin, D.,Liu, C.,Miller, R.,Schoellerman, J.,Luo, J.,Letavic, M.,Grasberger, B.,Maher, M.; Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.; Commun Biol, 4:174-174, 2021; PubMed: 33564124; DOI: 10.1038/s42003-021-01678-1

実験手法

X-RAY DIFFRACTION (3.01 Å)