6X5U

Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and NM5M2-Asn

6X5U の概要

• エントリーDOI: 10.2210/pdb6x5u/pdb
• 関連するPDBエントリー: 6X5H 6X5R 6X5S 6X5T
• 分子名称: Alpha-(1,6)-fucosyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: glycosyl transferase, fucosyl transferase, gt-b fold, inverting, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 506346.67

構造登録者

Kadirvelraj, R.,Wood, Z.A. (登録日: 2020-05-26, 公開日: 2020-10-07, 最終更新日: 2023-10-18)

• 主引用文献: Boruah, B.M.,Kadirvelraj, R.,Liu, L.,Ramiah, A.,Li, C.,Zong, G.,Bosman, G.P.,Yang, J.Y.,Wang, L.X.,Boons, G.J.,Wood, Z.A.,Moremen, K.W.; Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.; J.Biol.Chem., 295:17027-17045, 2020; PubMed: 33004438; DOI: 10.1074/jbc.RA120.014625

実験手法

X-RAY DIFFRACTION (3.2 Å)