6X27

Lon protease proteolytic domain complexed with bortezomib

Summary for 6X27

• Entry DOI: 10.2210/pdb6x27/pdb
• Related: 6WYS 6WZV 6X1M
• Descriptor: Lon protease homolog, mitochondrial, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PENTAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: covalent inhibitor, proteolytic domain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 12
• Total formula weight: 291683.35

Authors

Lee, C.C.,Spraggon, G. (deposition date: 2020-05-20, release date: 2021-04-14, Last modification date: 2023-10-18)

• Primary citation: Kingsley, L.J.,He, X.,McNeill, M.,Nelson, J.,Nikulin, V.,Ma, Z.,Lu, W.,Zhou, V.W.,Manuia, M.,Kreusch, A.,Gao, M.Y.,Witmer, D.,Vaillancourt, M.T.,Lu, M.,Greenblatt, S.,Lee, C.,Vashisht, A.,Bender, S.,Spraggon, G.,Michellys, P.Y.,Jia, Y.,Haling, J.R.,Lelais, G.; Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.; J.Med.Chem., 64:4857-4869, 2021; PubMed: 33821636; DOI: 10.1021/acs.jmedchem.0c02152

Experimental method

X-RAY DIFFRACTION (2.12 Å)