6X27

Lon protease proteolytic domain complexed with bortezomib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Lon protease homolog, mitochondrial	polymer	218	23788.2	12	UniProt (P36776) Pfam (PF05362)	Homo sapiens (Human)	LONHs,Lon protease-like protein,LONP,Mitochondrial ATP-dependent protease Lon,Serine protease 15
2	AA, CA, DA, EA, M... (I, J, K, L, A...)	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE	non-polymer		384.2	12	Chemie (BO2)
3	BA, N, P, R, V... (I, A, B, C, F...)	PENTAETHYLENE GLYCOL	non-polymer		238.3	6	Chemie (1PE)
4	FA, X (L, G)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	GA, HA, IA, JA, KA... (A, B, C, D, E...)	water	water		18.0	1591	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 754 - 959 (UniProt: P36776)

PDB	External Database	Details
Met 742	-	initiating methionine
Gly 743	-	expression tag
Ser 744	-	expression tag
Asp 745	-	expression tag
Lys 746	-	expression tag
Ile 747	-	expression tag
His 748	-	expression tag
His 749	-	expression tag
His 750	-	expression tag
His 751	-	expression tag
His 752	-	expression tag
His 753	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	285458.7
Non-Polymers*	Number of molecules	20
	Total formula weight	6224.7
All*	Total formula weight	291683.4

*Water molecules are not included.