6X27
Lon protease proteolytic domain complexed with bortezomib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Lon protease homolog, mitochondrial | polymer | 218 | 23788.2 | 12 | UniProt (P36776) Pfam (PF05362) In PDB | Homo sapiens (Human) | LONHs,Lon protease-like protein,LONP,Mitochondrial ATP-dependent protease Lon,Serine protease 15 |
2 | I, J, K, L, A... | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | non-polymer | 384.2 | 12 | Chemie (BO2) | |||
3 | I, A, B, C, F... | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 6 | Chemie (1PE) | |||
4 | L, G | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | water | water | 18.0 | 1591 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 754 - 959 (UniProt: P36776)
PDB | External Database | Details |
---|---|---|
Met 742 | - | initiating methionine |
Gly 743 | - | expression tag |
Ser 744 | - | expression tag |
Asp 745 | - | expression tag |
Lys 746 | - | expression tag |
Ile 747 | - | expression tag |
His 748 | - | expression tag |
His 749 | - | expression tag |
His 750 | - | expression tag |
His 751 | - | expression tag |
His 752 | - | expression tag |
His 753 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 285458.7 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 6224.7 | |
All* | Total formula weight | 291683.4 |