6X27
Lon protease proteolytic domain complexed with bortezomib
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004176 | molecular_function | ATP-dependent peptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006508 | biological_process | proteolysis |
| A | 0030163 | biological_process | protein catabolic process |
| B | 0004176 | molecular_function | ATP-dependent peptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0030163 | biological_process | protein catabolic process |
| C | 0004176 | molecular_function | ATP-dependent peptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006508 | biological_process | proteolysis |
| C | 0030163 | biological_process | protein catabolic process |
| D | 0004176 | molecular_function | ATP-dependent peptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0030163 | biological_process | protein catabolic process |
| E | 0004176 | molecular_function | ATP-dependent peptidase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006508 | biological_process | proteolysis |
| E | 0030163 | biological_process | protein catabolic process |
| F | 0004176 | molecular_function | ATP-dependent peptidase activity |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006508 | biological_process | proteolysis |
| F | 0030163 | biological_process | protein catabolic process |
| G | 0004176 | molecular_function | ATP-dependent peptidase activity |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006508 | biological_process | proteolysis |
| G | 0030163 | biological_process | protein catabolic process |
| H | 0004176 | molecular_function | ATP-dependent peptidase activity |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0030163 | biological_process | protein catabolic process |
| I | 0004176 | molecular_function | ATP-dependent peptidase activity |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0006508 | biological_process | proteolysis |
| I | 0030163 | biological_process | protein catabolic process |
| J | 0004176 | molecular_function | ATP-dependent peptidase activity |
| J | 0004252 | molecular_function | serine-type endopeptidase activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0006508 | biological_process | proteolysis |
| J | 0030163 | biological_process | protein catabolic process |
| K | 0004176 | molecular_function | ATP-dependent peptidase activity |
| K | 0004252 | molecular_function | serine-type endopeptidase activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0006508 | biological_process | proteolysis |
| K | 0030163 | biological_process | protein catabolic process |
| L | 0004176 | molecular_function | ATP-dependent peptidase activity |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0006508 | biological_process | proteolysis |
| L | 0030163 | biological_process | protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue BO2 A 1001 |
| Chain | Residue |
| A | LEU768 |
| A | PRO854 |
| A | SER855 |
| A | ALA856 |
| A | LYS898 |
| A | 1PE1002 |
| A | HOH1134 |
| A | ALA769 |
| A | TRP770 |
| A | THR771 |
| A | THR849 |
| A | PRO850 |
| A | LYS851 |
| A | ASP852 |
| A | GLY853 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE A 1002 |
| Chain | Residue |
| A | TRP770 |
| A | ALA772 |
| A | BO21001 |
| A | HOH1196 |
| A | HOH1201 |
| G | TRP770 |
| G | ALA772 |
| G | BO21001 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE B 1002 |
| Chain | Residue |
| B | TRP770 |
| B | BO21001 |
| B | HOH1101 |
| B | HOH1147 |
| B | HOH1192 |
| K | TRP770 |
| K | ALA772 |
| K | BO21001 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE C 1002 |
| Chain | Residue |
| C | TRP770 |
| C | ALA772 |
| C | BO21001 |
| C | HOH1156 |
| C | HOH1218 |
| L | TRP770 |
| L | ALA772 |
| L | BO21001 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE F 1002 |
| Chain | Residue |
| F | TRP770 |
| F | ALA772 |
| F | BO21001 |
| F | HOH1154 |
| F | HOH1202 |
| J | TRP770 |
| J | ALA772 |
| J | BO21001 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL G 1002 |
| Chain | Residue |
| G | LYS851 |
| G | ASP852 |
| G | BO21001 |
| G | HOH1159 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue 1PE H 1002 |
| Chain | Residue |
| E | TRP770 |
| E | ALA772 |
| E | BO21001 |
| H | TRP770 |
| H | ALA772 |
| H | BO21001 |
| H | HOH1186 |
| H | HOH1196 |
| H | HOH1201 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE I 1002 |
| Chain | Residue |
| D | TRP770 |
| D | ALA772 |
| D | BO21001 |
| I | TRP770 |
| I | ALA772 |
| I | BO21001 |
| I | HOH1184 |
| I | HOH1207 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL L 1002 |
| Chain | Residue |
| F | LYS918 |
| F | ASP919 |
| F | ASP922 |
| F | HOH1103 |
| L | ALA954 |
| L | ALA956 |
| site_id | AD1 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide BO2 B 1001 and SER B 855 |
| Chain | Residue |
| B | LEU768 |
| B | ALA769 |
| B | TRP770 |
| B | THR771 |
| B | SER776 |
| B | THR849 |
| B | PRO850 |
| B | LYS851 |
| B | ASP852 |
| B | GLY853 |
| B | PRO854 |
| B | ALA856 |
| B | GLY857 |
| B | THR880 |
| B | GLY881 |
| B | VAL892 |
| B | LYS898 |
| B | 1PE1002 |
| B | HOH1114 |
| B | HOH1163 |
| B | HOH1167 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide BO2 C 1001 and SER C 855 |
| Chain | Residue |
| C | THR849 |
| C | PRO850 |
| C | LYS851 |
| C | ASP852 |
| C | GLY853 |
| C | PRO854 |
| C | ALA856 |
| C | GLY857 |
| C | THR880 |
| C | GLY881 |
| C | VAL892 |
| C | LYS898 |
| C | 1PE1002 |
| C | HOH1114 |
| C | HOH1153 |
| C | LEU768 |
| C | ALA769 |
| C | TRP770 |
| C | THR771 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide BO2 D 1001 and SER D 855 |
| Chain | Residue |
| D | LEU768 |
| D | ALA769 |
| D | TRP770 |
| D | THR771 |
| D | THR849 |
| D | PRO850 |
| D | LYS851 |
| D | ASP852 |
| D | GLY853 |
| D | PRO854 |
| D | ALA856 |
| D | GLY857 |
| D | THR880 |
| D | GLY881 |
| D | VAL892 |
| D | LYS898 |
| D | HOH1121 |
| D | HOH1140 |
| I | 1PE1002 |
| site_id | AD4 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide BO2 E 1001 and SER E 855 |
| Chain | Residue |
| E | ALA769 |
| E | TRP770 |
| E | THR771 |
| E | MET810 |
| E | THR849 |
| E | PRO850 |
| E | LYS851 |
| E | ASP852 |
| E | GLY853 |
| E | PRO854 |
| E | ALA856 |
| E | GLY857 |
| E | THR880 |
| E | GLY881 |
| E | VAL892 |
| E | LYS898 |
| E | HOH1116 |
| E | HOH1119 |
| E | HOH1172 |
| H | 1PE1002 |
| site_id | AD5 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide BO2 F 1001 and SER F 855 |
| Chain | Residue |
| F | LEU768 |
| F | ALA769 |
| F | TRP770 |
| F | THR771 |
| F | THR849 |
| F | PRO850 |
| F | LYS851 |
| F | ASP852 |
| F | GLY853 |
| F | PRO854 |
| F | ALA856 |
| F | GLY857 |
| F | THR880 |
| F | GLY881 |
| F | VAL892 |
| F | LYS898 |
| F | 1PE1002 |
| F | HOH1108 |
| F | HOH1145 |
| F | HOH1186 |
| site_id | AD6 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide BO2 G 1001 and SER G 855 |
| Chain | Residue |
| A | 1PE1002 |
| G | ALA769 |
| G | TRP770 |
| G | THR771 |
| G | MET810 |
| G | THR849 |
| G | PRO850 |
| G | LYS851 |
| G | ASP852 |
| G | GLY853 |
| G | PRO854 |
| G | ALA856 |
| G | GLY857 |
| G | THR880 |
| G | GLY881 |
| G | VAL892 |
| G | LYS898 |
| G | GOL1002 |
| G | HOH1106 |
| G | HOH1130 |
| G | HOH1199 |
| site_id | AD7 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide BO2 H 1001 and SER H 855 |
| Chain | Residue |
| H | ALA769 |
| H | TRP770 |
| H | THR771 |
| H | MET810 |
| H | THR849 |
| H | PRO850 |
| H | LYS851 |
| H | ASP852 |
| H | GLY853 |
| H | PRO854 |
| H | ALA856 |
| H | GLY857 |
| H | THR880 |
| H | GLY881 |
| H | VAL892 |
| H | LYS898 |
| H | 1PE1002 |
| H | HOH1108 |
| H | HOH1121 |
| site_id | AD8 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide BO2 I 1001 and SER I 855 |
| Chain | Residue |
| I | LEU768 |
| I | ALA769 |
| I | TRP770 |
| I | THR771 |
| I | THR849 |
| I | PRO850 |
| I | LYS851 |
| I | ASP852 |
| I | GLY853 |
| I | PRO854 |
| I | ALA856 |
| I | GLY857 |
| I | THR880 |
| I | GLY881 |
| I | VAL892 |
| I | LYS898 |
| I | 1PE1002 |
| I | HOH1101 |
| I | HOH1114 |
| site_id | AD9 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide BO2 J 1001 and SER J 855 |
| Chain | Residue |
| F | 1PE1002 |
| J | LEU768 |
| J | ALA769 |
| J | TRP770 |
| J | THR771 |
| J | THR849 |
| J | PRO850 |
| J | LYS851 |
| J | ASP852 |
| J | GLY853 |
| J | PRO854 |
| J | ALA856 |
| J | GLY857 |
| J | THR880 |
| J | GLY881 |
| J | VAL892 |
| J | LYS898 |
| J | HOH1106 |
| J | HOH1110 |
| site_id | AE1 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide BO2 K 1001 and SER K 855 |
| Chain | Residue |
| B | 1PE1002 |
| K | LEU768 |
| K | ALA769 |
| K | TRP770 |
| K | THR771 |
| K | SER776 |
| K | THR849 |
| K | PRO850 |
| K | LYS851 |
| K | ASP852 |
| K | GLY853 |
| K | PRO854 |
| K | ALA856 |
| K | GLY857 |
| K | THR880 |
| K | GLY881 |
| K | VAL892 |
| K | LYS898 |
| K | HOH1112 |
| K | HOH1116 |
| K | HOH1140 |
| site_id | AE2 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide BO2 L 1001 and SER L 855 |
| Chain | Residue |
| C | 1PE1002 |
| L | LEU768 |
| L | ALA769 |
| L | TRP770 |
| L | THR771 |
| L | THR849 |
| L | PRO850 |
| L | LYS851 |
| L | ASP852 |
| L | GLY853 |
| L | PRO854 |
| L | ALA856 |
| L | GLY857 |
| L | THR880 |
| L | GLY881 |
| L | VAL892 |
| L | LYS898 |
| L | HOH1111 |
| L | HOH1112 |
Functional Information from PROSITE/UniProt
| site_id | PS01046 |
| Number of Residues | 9 |
| Details | LON_SER ATP-dependent serine proteases, lon family, serine active site. DGPSAGCTI |
| Chain | Residue | Details |
| A | ASP852-ILE860 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_03120 |
| Chain | Residue | Details |
| B | SER855 | |
| B | LYS898 | |
| C | SER855 | |
| C | LYS898 | |
| D | SER855 | |
| D | LYS898 | |
| E | SER855 | |
| E | LYS898 | |
| F | SER855 | |
| F | LYS898 | |
| G | SER855 | |
| G | LYS898 | |
| H | SER855 | |
| H | LYS898 | |
| I | SER855 | |
| I | LYS898 | |
| J | SER855 | |
| J | LYS898 | |
| K | SER855 | |
| K | LYS898 | |
| L | SER855 | |
| L | LYS898 | |
| A | SER855 | |
| A | LYS898 |
