6WZW

Ash1L SET domain in complex with AS-85

6WZW の概要

• エントリーDOI: 10.2210/pdb6wzw/pdb
• 分子名称: Histone-lysine N-methyltransferase ASH1L, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, S-ADENOSYLMETHIONINE, ... (6 entities in total)
• 機能のキーワード: methyltransferase, complex, protein binding, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27429.14

構造登録者

Li, H.,Deng, J.,Cierpicki, T.,Grembecka, J. (登録日: 2020-05-14, 公開日: 2021-04-07, 最終更新日: 2023-10-18)

• 主引用文献: Rogawski, D.S.,Deng, J.,Li, H.,Miao, H.,Borkin, D.,Purohit, T.,Song, J.,Chase, J.,Li, S.,Ndoj, J.,Klossowski, S.,Kim, E.,Mao, F.,Zhou, B.,Ropa, J.,Krotoska, M.Z.,Jin, Z.,Ernst, P.,Feng, X.,Huang, G.,Nishioka, K.,Kelly, S.,He, M.,Wen, B.,Sun, D.,Muntean, A.,Dou, Y.,Maillard, I.,Cierpicki, T.,Grembecka, J.; Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.; Nat Commun, 12:2792-2792, 2021; PubMed: 33990599; DOI: 10.1038/s41467-021-23152-6

実験手法

X-RAY DIFFRACTION (1.69 Å)