6WWZ

Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein

Summary for 6WWZ

• Entry DOI: 10.2210/pdb6wwz/pdb
• EMDB information: 21950
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, chemokine, chemokine receptor, complex, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 173507.66

Authors

Wasilko, D.J.,Johnson, Z.L.,Ammirati, M.,Han, S.,Wu, H. (deposition date: 2020-05-09, release date: 2020-06-24, Last modification date: 2020-07-01)

• Primary citation: Wasilko, D.J.,Johnson, Z.L.,Ammirati, M.,Che, Y.,Griffor, M.C.,Han, S.,Wu, H.; Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.; Nat Commun, 11:3031-3031, 2020; PubMed: 32541785; DOI: 10.1038/s41467-020-16820-6

Experimental method

ELECTRON MICROSCOPY (3.34 Å)