6WVW

Crystal structure of the R59P-SNAP25 containing SNARE complex

Summary for 6WVW

• Entry DOI: 10.2210/pdb6wvw/pdb
• Descriptor: Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ... (7 entities in total)
• Functional Keywords: snare complex, synaptic vesicle fusion, exocytosis
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 8
• Total formula weight: 62087.74

Authors

Zhou, Q.,White, K.I.,Brunger, A.T. (deposition date: 2020-05-07, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Alten, B.,Zhou, Q.,Shin, O.H.,Esquivies, L.,Lin, P.Y.,White, K.I.,Sun, R.,Chung, W.K.,Monteggia, L.M.,Brunger, A.T.,Kavalali, E.T.; Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.; Neuron, 109:59-72.e5, 2021; PubMed: 33147442; DOI: 10.1016/j.neuron.2020.10.012

Experimental method

X-RAY DIFFRACTION (2.11 Å)