6WPH

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC

Summary for 6WPH

• Entry DOI: 10.2210/pdb6wph/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, DNA Primer 21-mer, ... (9 entities in total)
• Functional Keywords: reverse transcriptase, ternary complex, (-)ftc, chain terminator, emtricitabine, stereochemistry, transferase, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1); More
• Total number of polymer chains: 4
• Total formula weight: 133070.13

Authors

Bertoletti, N.,Anderson, K.S. (deposition date: 2020-04-27, release date: 2020-11-04, Last modification date: 2024-05-29)

• Primary citation: Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Anderson, K.S.; Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance.; Molecules, 25:-, 2020; PubMed: 33096918; DOI: 10.3390/molecules25204868

Experimental method

X-RAY DIFFRACTION (2.72 Å)