6WPH

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC

6WPH の概要

• エントリーDOI: 10.2210/pdb6wph/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, DNA Primer 21-mer, ... (9 entities in total)
• 機能のキーワード: reverse transcriptase, ternary complex, (-)ftc, chain terminator, emtricitabine, stereochemistry, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 133070.13

構造登録者

Bertoletti, N.,Anderson, K.S. (登録日: 2020-04-27, 公開日: 2020-11-04, 最終更新日: 2024-05-29)

• 主引用文献: Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Anderson, K.S.; Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance.; Molecules, 25:-, 2020; PubMed: 33096918; DOI: 10.3390/molecules25204868

実験手法

X-RAY DIFFRACTION (2.72 Å)