6WOL

Next generation monomeric IgG4 Fc bound to neonatal Fc receptor

6WOL の概要

• エントリーDOI: 10.2210/pdb6wol/pdb
• 分子名称: Immunoglobulin heavy constant gamma 4, IgG receptor FcRn large subunit p51, Beta-2-microglobulin, ... (5 entities in total)
• 機能のキーワード: antibody constant region, fragment crystallizable, mutated, immune system, neonatal fc receptor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 66685.69

構造登録者

Oganesyan, V.Y.,Shan, L.,van Dyk, N.,Dall'Acqua, W.F. (登録日: 2020-04-24, 公開日: 2021-09-15, 最終更新日: 2023-10-18)

• 主引用文献: Shan, L.,Dyk, N.V.,Haskins, N.,Cook, K.M.,Rosenthal, K.L.,Mazor, R.,Dragulin-Otto, S.,Jiang, Y.,Wu, H.,Dall'Acqua, W.F.,Borrok, M.J.,Damschroder, M.M.,Oganesyan, V.; In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.; Commun Biol, 4:1048-1048, 2021; PubMed: 34497355; DOI: 10.1038/s42003-021-02565-5

実験手法

X-RAY DIFFRACTION (2.49 Å)