6WOF
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol hexakisphosphate and Mg, presoaked with 5-IP7, Mg and Fluoride, soaking 20min in the absence of Fluoride.
Summary for 6WOF
| Entry DOI | 10.2210/pdb6wof/pdb |
| Descriptor | Diphosphoinositol polyphosphate phosphohydrolase 1, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 20346.78 |
| Authors | Zong, G.N.,Wang, H.C.,Shears, S.B. (deposition date: 2020-04-24, release date: 2021-03-03, Last modification date: 2024-03-06) |
| Primary citation | Zong, G.,Jork, N.,Hostachy, S.,Fiedler, D.,Jessen, H.J.,Shears, S.B.,Wang, H. New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. Faseb J., 35:e21275-e21275, 2021 Cited by PubMed: 33475202DOI: 10.1096/fj.202001489R PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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