6WOF
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol hexakisphosphate and Mg, presoaked with 5-IP7, Mg and Fluoride, soaking 20min in the absence of Fluoride.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | GLY50 |
| A | GLY51 |
| A | GLU70 |
| A | MG502 |
| A | IHP506 |
| A | HOH612 |
| A | HOH614 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | MG501 |
| A | MG503 |
| A | IHP506 |
| A | HOH612 |
| A | HOH619 |
| A | HOH680 |
| A | HOH736 |
| A | GLU66 |
| A | GLU70 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | MG502 |
| A | IHP506 |
| A | HOH601 |
| A | HOH602 |
| A | HOH612 |
| A | HOH650 |
| A | HOH695 |
| A | HOH736 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | ASN86 |
| A | GLN136 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | ARG27 |
| A | SER28 |
| A | SER30 |
| A | GLU32 |
| A | GLU33 |
| A | HOH720 |
| site_id | AC6 |
| Number of Residues | 29 |
| Details | binding site for residue IHP A 506 |
| Chain | Residue |
| A | ARG10 |
| A | LYS18 |
| A | ARG20 |
| A | SER39 |
| A | SER40 |
| A | ARG41 |
| A | ILE47 |
| A | GLY50 |
| A | GLY51 |
| A | GLY52 |
| A | GLU70 |
| A | ARG89 |
| A | HIS91 |
| A | ARG115 |
| A | LYS133 |
| A | MG501 |
| A | MG502 |
| A | MG503 |
| A | HOH602 |
| A | HOH612 |
| A | HOH613 |
| A | HOH614 |
| A | HOH622 |
| A | HOH632 |
| A | HOH634 |
| A | HOH637 |
| A | HOH650 |
| A | HOH680 |
| A | HOH695 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG |
| Chain | Residue | Details |
| A | GLY51-GLY72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
