6WNK

Macrocyclic peptides TDI5575 that selectively inhibit the Mycobacterium tuberculosis proteasome

Summary for 6WNK

• Entry DOI: 10.2210/pdb6wnk/pdb
• Related PRD ID: PRD_002377
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, (12S,15S)-N-[(2-fluorophenyl)methyl]-10,13-dioxo-12-{2-oxo-2-[(2R)-2-phenylpyrrolidin-1-yl]ethyl}-2-oxa-11,14-diazatricyclo[15.2.2.1~3,7~]docosa-1(19),3(22),4,6,17,20-hexaene-15-carboxamide, ... (6 entities in total)
• Functional Keywords: mycobacterium tuberculosis, proteasome inhibitor, macrocyclic peptides, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 730000.32

Authors

Hsu, H.C.,Li, H. (deposition date: 2020-04-22, release date: 2021-04-28, Last modification date: 2023-10-18)

• Primary citation: Zhang, H.,Hsu, H.C.,Kahne, S.C.,Hara, R.,Zhan, W.,Jiang, X.,Burns-Huang, K.,Ouellette, T.,Imaeda, T.,Okamoto, R.,Kawasaki, M.,Michino, M.,Wong, T.T.,Toita, A.,Yukawa, T.,Moraca, F.,Vendome, J.,Saha, P.,Sato, K.,Aso, K.,Ginn, J.,Meinke, P.T.,Foley, M.,Nathan, C.F.,Darwin, K.H.,Li, H.,Lin, G.; Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.; J.Med.Chem., 64:6262-6272, 2021; PubMed: 33949190; DOI: 10.1021/acs.jmedchem.1c00296

Experimental method

X-RAY DIFFRACTION (2.28 Å)