6WNK
Macrocyclic peptides TDI5575 that selectively inhibit the Mycobacterium tuberculosis proteasome
Summary for 6WNK
Entry DOI | 10.2210/pdb6wnk/pdb |
Related PRD ID | PRD_002377 |
Descriptor | Proteasome subunit alpha, Proteasome subunit beta, (12S,15S)-N-[(2-fluorophenyl)methyl]-10,13-dioxo-12-{2-oxo-2-[(2R)-2-phenylpyrrolidin-1-yl]ethyl}-2-oxa-11,14-diazatricyclo[15.2.2.1~3,7~]docosa-1(19),3(22),4,6,17,20-hexaene-15-carboxamide, ... (6 entities in total) |
Functional Keywords | mycobacterium tuberculosis, proteasome inhibitor, macrocyclic peptides, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mycobacterium tuberculosis More |
Total number of polymer chains | 28 |
Total formula weight | 730000.32 |
Authors | |
Primary citation | Zhang, H.,Hsu, H.C.,Kahne, S.C.,Hara, R.,Zhan, W.,Jiang, X.,Burns-Huang, K.,Ouellette, T.,Imaeda, T.,Okamoto, R.,Kawasaki, M.,Michino, M.,Wong, T.T.,Toita, A.,Yukawa, T.,Moraca, F.,Vendome, J.,Saha, P.,Sato, K.,Aso, K.,Ginn, J.,Meinke, P.T.,Foley, M.,Nathan, C.F.,Darwin, K.H.,Li, H.,Lin, G. Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome. J.Med.Chem., 64:6262-6272, 2021 Cited by PubMed: 33949190DOI: 10.1021/acs.jmedchem.1c00296 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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