6WMN

Human poly-N-acetyl-lactosamine synthase structure demonstrates a modular assembly of catalytic subsites for GT-A glycosyltransferases

Summary for 6WMN

• Entry DOI: 10.2210/pdb6wmn/pdb
• Related: 6WMM
• Descriptor: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: glycosyltransferase, gt-a fold, poly lacnac synthesis, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 174209.49

Authors

Kadirvelraj, R.,Wood, Z.A. (deposition date: 2020-04-21, release date: 2020-12-02, Last modification date: 2023-10-18)

• Primary citation: Kadirvelraj, R.,Yang, J.Y.,Kim, H.W.,Sanders, J.H.,Moremen, K.W.,Wood, Z.A.; Comparison of human poly-N-acetyl-lactosamine synthase structure with GT-A fold glycosyltransferases supports a modular assembly of catalytic subsites.; J.Biol.Chem., 296:100110-100110, 2020; PubMed: 33229435; DOI: 10.1074/jbc.RA120.015305

Experimental method

X-RAY DIFFRACTION (2.04 Å)