6WKJ
Crystal structure of pentalenene synthase mutant F76H complexed with 12,13-difluorofarnesyl diphosphate
Summary for 6WKJ
Entry DOI | 10.2210/pdb6wkj/pdb |
Descriptor | Pentalenene synthase, (2E,6E)-12-fluoro-11-(fluoromethyl)-3,7-dimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate (3 entities in total) |
Functional Keywords | terpene synthase, terpene synthase fold, sesquiterpene, fluoro analog, metal binding, metal binding protein, lyase-inhibitor complex, lyase/inhibitor |
Biological source | Streptomyces sp. |
Total number of polymer chains | 2 |
Total formula weight | 76501.08 |
Authors | Prem Kumar, R.,Matos, J.O.,Oprian, D.D. (deposition date: 2020-04-16, release date: 2020-08-26, Last modification date: 2023-10-18) |
Primary citation | Matos, J.O.,Kumar, R.P.,Ma, A.C.,Patterson, M.,Krauss, I.J.,Oprian, D.D. Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase. Biochemistry, 59:3271-3283, 2020 Cited by PubMed: 32786410DOI: 10.1021/acs.biochem.0c00518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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