6WHE
Structure of phosphomimetic Rab8a GTPase (T72E) in the GTP-bound state
Summary for 6WHE
Entry DOI | 10.2210/pdb6whe/pdb |
Related | 6sq2 |
Descriptor | Ras-related protein Rab-8A, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | rab gtpase, membrane trafficking, leucine-rich repeat kinase 2 (lrrk2), switch 2 phosphorylation, effector recruitment, golgi membranes, ciliogenesis, parkinson's disease, rab-interacting lysosomal protein-like 2 (rilpl2), signaling protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 43341.45 |
Authors | Waschbusch, D.,Khan, A.R. (deposition date: 2020-04-08, release date: 2021-03-10, Last modification date: 2023-10-18) |
Primary citation | Waschbusch, D.,Purlyte, E.,Khan, A.R. Dual arginine recognition of LRRK2 phosphorylated Rab GTPases. Biophys.J., 120:1846-1855, 2021 Cited by PubMed: 33887226DOI: 10.1016/j.bpj.2021.03.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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