6WHE

Structure of phosphomimetic Rab8a GTPase (T72E) in the GTP-bound state

Summary for 6WHE

Entry DOI	10.2210/pdb6whe/pdb
Related	6sq2
Descriptor	Ras-related protein Rab-8A, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	rab gtpase, membrane trafficking, leucine-rich repeat kinase 2 (lrrk2), switch 2 phosphorylation, effector recruitment, golgi membranes, ciliogenesis, parkinson's disease, rab-interacting lysosomal protein-like 2 (rilpl2), signaling protein, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	43341.45
Authors	Waschbusch, D.,Khan, A.R. (deposition date: 2020-04-08, release date: 2021-03-10, Last modification date: 2023-10-18)
Primary citation	Waschbusch, D.,Purlyte, E.,Khan, A.R. Dual arginine recognition of LRRK2 phosphorylated Rab GTPases. Biophys.J., 120:1846-1855, 2021 Cited by PubMed: 33887226 DOI: 10.1016/j.bpj.2021.03.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation