6WGX
Cocrystal of BRD4(D1) with a selective inhibitor
Summary for 6WGX
Entry DOI | 10.2210/pdb6wgx/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 4-(1-{1-[2-(dimethylamino)ethyl]piperidin-4-yl}-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-5-yl)-N-(3,5-dimethylphenyl)pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | brd4, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31636.42 |
Authors | Johnson, J.A.,Cui, H.,Shi, K.,Aihara, H.,Pomerantz, W.C.K. (deposition date: 2020-04-06, release date: 2020-10-07, Last modification date: 2023-10-18) |
Primary citation | Cui, H.,Divakaran, A.,Pandey, A.K.,Johnson, J.A.,Zahid, H.,Hoell, Z.J.,Ellingson, M.O.,Shi, K.,Aihara, H.,Harki, D.A.,Pomerantz, W.C.K. Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*. Angew.Chem.Int.Ed.Engl., 60:1220-1226, 2021 Cited by PubMed: 32975004DOI: 10.1002/anie.202008625 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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