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6WGX

Cocrystal of BRD4(D1) with a selective inhibitor

Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH318
BASN116
BHOH337

site_idAC2
Number of Residues15
Detailsbinding site for residue U0D A 202
ChainResidue
APRO82
APHE83
ALEU92
AASN93
ATYR97
AMET105
AMET132
AASN140
AILE146
AEDO204
AHOH385
AHOH406
AHOH407
BASP145
ATRP81

site_idAC3
Number of Residues2
Detailsbinding site for residue EDO A 203
ChainResidue
ATRP81
BTRP81

site_idAC4
Number of Residues3
Detailsbinding site for residue EDO A 204
ChainResidue
AU0D202
BPHE79
BASP145

site_idAC5
Number of Residues3
Detailsbinding site for residue EDO A 205
ChainResidue
ATYR139
AASN140
AASP144

site_idAC6
Number of Residues6
Detailsbinding site for residue EDO B 201
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135
BHOH341

site_idAC7
Number of Residues13
Detailsbinding site for residue U0D B 202
ChainResidue
AASP145
BTRP81
BPRO82
BPHE83
BLEU92
BTYR97
BMET105
BMET132
BASN135
BASN140
BILE146
BHOH381
BHOH414

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

226707

PDB entries from 2024-10-30

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