6WEW

Crystal structures of human E-NPP 1: bound to N-{4-[(7-methoxyquinolin-4-yl)oxy]phenyl}sulfuric diamide

This is a non-PDB format compatible entry.

Summary for 6WEW

• Entry DOI: 10.2210/pdb6wew/pdb
• Descriptor: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, 1,2-ETHANEDIOL, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: human e-npp 1; drug discovery; inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 215035.33

Authors

Peat, T.S.,Dennis, M.,Newman, J. (deposition date: 2020-04-03, release date: 2020-09-09, Last modification date: 2023-10-18)

• Primary citation: Dennis, M.L.,Newman, J.,Dolezal, O.,Hattarki, M.,Surjadi, R.N.,Nuttall, S.D.,Pham, T.,Nebl, T.,Camerino, M.,Khoo, P.S.,Monahan, B.J.,Peat, T.S.; Crystal structures of human ENPP1 in apo and bound forms.; Acta Crystallogr D Struct Biol, 76:889-898, 2020; PubMed: 32876064; DOI: 10.1107/S2059798320010505

Experimental method

X-RAY DIFFRACTION (2.73 Å)