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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6WEW

Crystal structures of human E-NPP 1: bound to N-{4-[(7-methoxyquinolin-4-yl)oxy]phenyl}sulfuric diamide

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AbA0003676molecular_functionnucleic acid binding
AbA0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
AbA0004527molecular_functionexonuclease activity
AbA0004528molecular_functionphosphodiesterase I activity
AbA0004551molecular_functiondinucleotide phosphatase activity
AbA0005044molecular_functionscavenger receptor activity
AbA0005158molecular_functioninsulin receptor binding
AbA0005509molecular_functioncalcium ion binding
AbA0005515molecular_functionprotein binding
AbA0005524molecular_functionATP binding
AbA0005576cellular_componentextracellular region
AbA0005615cellular_componentextracellular space
AbA0005765cellular_componentlysosomal membrane
AbA0005886cellular_componentplasma membrane
AbA0006091biological_processgeneration of precursor metabolites and energy
AbA0006796biological_processphosphate-containing compound metabolic process
AbA0006955biological_processimmune response
AbA0008270molecular_functionzinc ion binding
AbA0009143biological_processnucleoside triphosphate catabolic process
AbA0009986cellular_componentcell surface
AbA0010035biological_processobsolete response to inorganic substance
AbA0010467biological_processgene expression
AbA0016020cellular_componentmembrane
AbA0016192biological_processvesicle-mediated transport
AbA0016323cellular_componentbasolateral plasma membrane
AbA0016787molecular_functionhydrolase activity
AbA0016788molecular_functionhydrolase activity, acting on ester bonds
AbA0016791molecular_functionphosphatase activity
AbA0030247molecular_functionpolysaccharide binding
AbA0030282biological_processbone mineralization
AbA0030308biological_processnegative regulation of cell growth
AbA0030318biological_processmelanocyte differentiation
AbA0030500biological_processregulation of bone mineralization
AbA0030502biological_processnegative regulation of bone mineralization
AbA0030505biological_processinorganic diphosphate transport
AbA0030643biological_processintracellular phosphate ion homeostasis
AbA0030730biological_processsequestering of triglyceride
AbA0031214biological_processbiomineral tissue development
AbA0031953biological_processnegative regulation of protein autophosphorylation
AbA0032869biological_processcellular response to insulin stimulus
AbA0033198biological_processresponse to ATP
AbA0036219molecular_functionGTP diphosphatase activity
AbA0036221molecular_functionUTP diphosphatase activity
AbA0042803molecular_functionprotein homodimerization activity
AbA0045599biological_processnegative regulation of fat cell differentiation
AbA0045719biological_processnegative regulation of glycogen biosynthetic process
AbA0046034biological_processATP metabolic process
AbA0046325biological_processnegative regulation of glucose import
AbA0046627biological_processnegative regulation of insulin receptor signaling pathway
AbA0046872molecular_functionmetal ion binding
AbA0047429molecular_functionnucleoside triphosphate diphosphatase activity
AbA0047693molecular_functionATP diphosphatase activity
AbA0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
AbA0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
AbA0055062biological_processphosphate ion homeostasis
AbA0090304biological_processnucleic acid metabolic process
AbA0106177molecular_functioncyclic-GMP-AMP hydrolase activity
AbA0110148biological_processobsolete biomineralization
AbA1990787biological_processnegative regulation of hh target transcription factor activity
BaB0003676molecular_functionnucleic acid binding
BaB0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
BaB0004527molecular_functionexonuclease activity
BaB0004528molecular_functionphosphodiesterase I activity
BaB0004551molecular_functiondinucleotide phosphatase activity
BaB0005044molecular_functionscavenger receptor activity
BaB0005158molecular_functioninsulin receptor binding
BaB0005509molecular_functioncalcium ion binding
BaB0005515molecular_functionprotein binding
BaB0005524molecular_functionATP binding
BaB0005576cellular_componentextracellular region
BaB0005615cellular_componentextracellular space
BaB0005765cellular_componentlysosomal membrane
BaB0005886cellular_componentplasma membrane
BaB0006091biological_processgeneration of precursor metabolites and energy
BaB0006796biological_processphosphate-containing compound metabolic process
BaB0006955biological_processimmune response
BaB0008270molecular_functionzinc ion binding
BaB0009143biological_processnucleoside triphosphate catabolic process
BaB0009986cellular_componentcell surface
BaB0010035biological_processobsolete response to inorganic substance
BaB0010467biological_processgene expression
BaB0016020cellular_componentmembrane
BaB0016192biological_processvesicle-mediated transport
BaB0016323cellular_componentbasolateral plasma membrane
BaB0016787molecular_functionhydrolase activity
BaB0016788molecular_functionhydrolase activity, acting on ester bonds
BaB0016791molecular_functionphosphatase activity
BaB0030247molecular_functionpolysaccharide binding
BaB0030282biological_processbone mineralization
BaB0030308biological_processnegative regulation of cell growth
BaB0030318biological_processmelanocyte differentiation
BaB0030500biological_processregulation of bone mineralization
BaB0030502biological_processnegative regulation of bone mineralization
BaB0030505biological_processinorganic diphosphate transport
BaB0030643biological_processintracellular phosphate ion homeostasis
BaB0030730biological_processsequestering of triglyceride
BaB0031214biological_processbiomineral tissue development
BaB0031953biological_processnegative regulation of protein autophosphorylation
BaB0032869biological_processcellular response to insulin stimulus
BaB0033198biological_processresponse to ATP
BaB0036219molecular_functionGTP diphosphatase activity
BaB0036221molecular_functionUTP diphosphatase activity
BaB0042803molecular_functionprotein homodimerization activity
BaB0045599biological_processnegative regulation of fat cell differentiation
BaB0045719biological_processnegative regulation of glycogen biosynthetic process
BaB0046034biological_processATP metabolic process
BaB0046325biological_processnegative regulation of glucose import
BaB0046627biological_processnegative regulation of insulin receptor signaling pathway
BaB0046872molecular_functionmetal ion binding
BaB0047429molecular_functionnucleoside triphosphate diphosphatase activity
BaB0047693molecular_functionATP diphosphatase activity
BaB0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
BaB0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
BaB0055062biological_processphosphate ion homeostasis
BaB0090304biological_processnucleic acid metabolic process
BaB0106177molecular_functioncyclic-GMP-AMP hydrolase activity
BaB0110148biological_processobsolete biomineralization
BaB1990787biological_processnegative regulation of hh target transcription factor activity
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC
ChainResidueDetails
AbACYS120-CYS140
AbACYS164-CYS184
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues150
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AbAMET1-LYS76
BaBMET1-LYS76
site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
AbAVAL77-LEU97
BaBVAL77-LEU97
site_idSWS_FT_FI3
Number of Residues1654
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AbALYS98-ASP925
BaBLYS98-ASP925
site_idSWS_FT_FI4
Number of Residues2
DetailsACT_SITE: AMP-threonine intermediate => ECO:0000250|UniProtKB:P06802
ChainResidueDetails
AbATHR256
BaBTHR256
site_idSWS_FT_FI5
Number of Residues34
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P06802
ChainResidueDetails
AbAASP218
AbAHIS424
AbASER532
AbAHIS535
AbAASP800
AbAASP802
AbAASP804
AbAARG806
AbAASP808
BaBASP218
BaBTHR256
AbATHR256
BaBASN277
BaBLEU290
BaBLYS295
BaBTYR340
BaBASP376
BaBHIS380
BaBASP423
BaBHIS424
BaBSER532
BaBHIS535
AbAASN277
BaBASP800
BaBASP802
BaBASP804
BaBARG806
BaBASP808
AbALEU290
AbALYS295
AbATYR340
AbAASP376
AbAHIS380
AbAASP423
site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Cleavage => ECO:0000250|UniProtKB:P06802
ChainResidueDetails
AbAALA102
BaBALA102
site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6
ChainResidueDetails
AbALYS915
BaBLYS915
site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3
ChainResidueDetails
AbATHR256
BaBTHR256
site_idSWS_FT_FI9
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AbAASN179
BaBASN585
BaBASN700
BaBASN731
AbAASN285
AbAASN477
AbAASN585
AbAASN700
AbAASN731
BaBASN179
BaBASN285
BaBASN477
site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
AbAASN341
BaBASN341
site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AbAASN643
AbAASN748
BaBASN643
BaBASN748

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PDB entries from 2024-07-10

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