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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6WEW

Crystal structures of human E-NPP 1: bound to N-{4-[(7-methoxyquinolin-4-yl)oxy]phenyl}sulfuric diamide

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AbA0003676molecular_functionnucleic acid binding
AbA0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
AbA0004527molecular_functionexonuclease activity
AbA0004528molecular_functionphosphodiesterase I activity
AbA0004551molecular_functiondinucleotide phosphatase activity
AbA0005044molecular_functionscavenger receptor activity
AbA0005158molecular_functioninsulin receptor binding
AbA0005509molecular_functioncalcium ion binding
AbA0005515molecular_functionprotein binding
AbA0005524molecular_functionATP binding
AbA0005576cellular_componentextracellular region
AbA0005615cellular_componentextracellular space
AbA0005765cellular_componentlysosomal membrane
AbA0005886cellular_componentplasma membrane
AbA0006091biological_processgeneration of precursor metabolites and energy
AbA0006796biological_processphosphate-containing compound metabolic process
AbA0006955biological_processimmune response
AbA0008270molecular_functionzinc ion binding
AbA0009143biological_processnucleoside triphosphate catabolic process
AbA0009986cellular_componentcell surface
AbA0010035biological_processobsolete response to inorganic substance
AbA0010467biological_processgene expression
AbA0016020cellular_componentmembrane
AbA0016192biological_processvesicle-mediated transport
AbA0016323cellular_componentbasolateral plasma membrane
AbA0016787molecular_functionhydrolase activity
AbA0016791molecular_functionphosphatase activity
AbA0030247molecular_functionpolysaccharide binding
AbA0030282biological_processbone mineralization
AbA0030308biological_processnegative regulation of cell growth
AbA0030318biological_processmelanocyte differentiation
AbA0030500biological_processregulation of bone mineralization
AbA0030502biological_processnegative regulation of bone mineralization
AbA0030505biological_processinorganic diphosphate transport
AbA0030643biological_processintracellular phosphate ion homeostasis
AbA0031214biological_processbiomineral tissue development
AbA0032869biological_processcellular response to insulin stimulus
AbA0033198biological_processresponse to ATP
AbA0036219molecular_functionGTP diphosphatase activity
AbA0036221molecular_functionUTP diphosphatase activity
AbA0042803molecular_functionprotein homodimerization activity
AbA0045599biological_processnegative regulation of fat cell differentiation
AbA0045719biological_processnegative regulation of glycogen biosynthetic process
AbA0046034biological_processATP metabolic process
AbA0046325biological_processnegative regulation of D-glucose import
AbA0046627biological_processnegative regulation of insulin receptor signaling pathway
AbA0046872molecular_functionmetal ion binding
AbA0047429molecular_functionnucleoside triphosphate diphosphatase activity
AbA0047693molecular_functionATP diphosphatase activity
AbA0048513biological_processanimal organ development
AbA0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
AbA0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
AbA0055062biological_processphosphate ion homeostasis
AbA0090304biological_processnucleic acid metabolic process
AbA0106177molecular_functioncyclic-GMP-AMP hydrolase activity
AbA0110148biological_processobsolete biomineralization
AbA1990787biological_processnegative regulation of hh target transcription factor activity
BaB0003676molecular_functionnucleic acid binding
BaB0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
BaB0004527molecular_functionexonuclease activity
BaB0004528molecular_functionphosphodiesterase I activity
BaB0004551molecular_functiondinucleotide phosphatase activity
BaB0005044molecular_functionscavenger receptor activity
BaB0005158molecular_functioninsulin receptor binding
BaB0005509molecular_functioncalcium ion binding
BaB0005515molecular_functionprotein binding
BaB0005524molecular_functionATP binding
BaB0005576cellular_componentextracellular region
BaB0005615cellular_componentextracellular space
BaB0005765cellular_componentlysosomal membrane
BaB0005886cellular_componentplasma membrane
BaB0006091biological_processgeneration of precursor metabolites and energy
BaB0006796biological_processphosphate-containing compound metabolic process
BaB0006955biological_processimmune response
BaB0008270molecular_functionzinc ion binding
BaB0009143biological_processnucleoside triphosphate catabolic process
BaB0009986cellular_componentcell surface
BaB0010035biological_processobsolete response to inorganic substance
BaB0010467biological_processgene expression
BaB0016020cellular_componentmembrane
BaB0016192biological_processvesicle-mediated transport
BaB0016323cellular_componentbasolateral plasma membrane
BaB0016787molecular_functionhydrolase activity
BaB0016791molecular_functionphosphatase activity
BaB0030247molecular_functionpolysaccharide binding
BaB0030282biological_processbone mineralization
BaB0030308biological_processnegative regulation of cell growth
BaB0030318biological_processmelanocyte differentiation
BaB0030500biological_processregulation of bone mineralization
BaB0030502biological_processnegative regulation of bone mineralization
BaB0030505biological_processinorganic diphosphate transport
BaB0030643biological_processintracellular phosphate ion homeostasis
BaB0031214biological_processbiomineral tissue development
BaB0032869biological_processcellular response to insulin stimulus
BaB0033198biological_processresponse to ATP
BaB0036219molecular_functionGTP diphosphatase activity
BaB0036221molecular_functionUTP diphosphatase activity
BaB0042803molecular_functionprotein homodimerization activity
BaB0045599biological_processnegative regulation of fat cell differentiation
BaB0045719biological_processnegative regulation of glycogen biosynthetic process
BaB0046034biological_processATP metabolic process
BaB0046325biological_processnegative regulation of D-glucose import
BaB0046627biological_processnegative regulation of insulin receptor signaling pathway
BaB0046872molecular_functionmetal ion binding
BaB0047429molecular_functionnucleoside triphosphate diphosphatase activity
BaB0047693molecular_functionATP diphosphatase activity
BaB0048513biological_processanimal organ development
BaB0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
BaB0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
BaB0055062biological_processphosphate ion homeostasis
BaB0090304biological_processnucleic acid metabolic process
BaB0106177molecular_functioncyclic-GMP-AMP hydrolase activity
BaB0110148biological_processobsolete biomineralization
BaB1990787biological_processnegative regulation of hh target transcription factor activity
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC
ChainResidueDetails
AbACYS120-CYS140
AbACYS164-CYS184
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsDomain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues800
DetailsRegion: {"description":"Phosphodiesterase","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues50
DetailsRegion: {"description":"Linker","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"AMP-threonine intermediate","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues34
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q924C3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsDomain: {"description":"SMB 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-03

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