6WEP
Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site
Summary for 6WEP
| Entry DOI | 10.2210/pdb6wep/pdb |
| Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total) |
| Functional Keywords | ts, ts-dhfr, transferase |
| Biological source | Cryptosporidium hominis |
| Total number of polymer chains | 2 |
| Total formula weight | 122924.76 |
| Authors | Czyzyk, D.J.,Ruiz, V.G.,Kumar, V.P.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2020-04-02, release date: 2020-06-17, Last modification date: 2023-10-18) |
| Primary citation | Ruiz, V.G.,Czyzyk, D.J.,Kumar, V.P.,Jorgensen, W.L.,Anderson, K.S. Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitor Bioorg.Med.Chem.Lett., 30:127292-127298, 2020 Cited by DOI: 10.1016/j.bmcl.2020.127292PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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