6WEP
Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | binding site for residue NDP A 601 |
Chain | Residue |
A | VAL10 |
A | THR58 |
A | SER61 |
A | ILE75 |
A | SER76 |
A | SER77 |
A | SER78 |
A | ARG92 |
A | GLY114 |
A | GLY115 |
A | GLU116 |
A | ALA11 |
A | SER117 |
A | THR145 |
A | MTX602 |
A | HOH703 |
A | ILE19 |
A | GLY23 |
A | GLN24 |
A | LEU25 |
A | GLY55 |
A | ARG56 |
A | LYS57 |
site_id | AC2 |
Number of Residues | 17 |
Details | binding site for residue MTX A 602 |
Chain | Residue |
A | VAL9 |
A | VAL10 |
A | ALA11 |
A | LEU25 |
A | ASP32 |
A | LEU33 |
A | PHE36 |
A | SER37 |
A | THR58 |
A | ILE62 |
A | LEU67 |
A | ARG70 |
A | CYS113 |
A | TYR119 |
A | THR134 |
A | NDP601 |
B | ARG65 |
site_id | AC3 |
Number of Residues | 23 |
Details | binding site for residue NDP B 601 |
Chain | Residue |
B | VAL10 |
B | ALA11 |
B | ILE19 |
B | GLY23 |
B | GLN24 |
B | LEU25 |
B | GLY55 |
B | ARG56 |
B | LYS57 |
B | THR58 |
B | SER61 |
B | ILE75 |
B | SER76 |
B | SER77 |
B | ARG92 |
B | GLY114 |
B | GLY115 |
B | GLU116 |
B | SER117 |
B | ILE118 |
B | ASP121 |
B | THR145 |
B | MTX602 |
site_id | AC4 |
Number of Residues | 19 |
Details | binding site for residue MTX B 602 |
Chain | Residue |
A | ARG65 |
B | VAL9 |
B | VAL10 |
B | ALA11 |
B | LEU25 |
B | ASP32 |
B | LEU33 |
B | LYS34 |
B | PHE36 |
B | SER37 |
B | THR58 |
B | ILE62 |
B | LEU67 |
B | ARG70 |
B | CYS113 |
B | TYR119 |
B | THR134 |
B | NDP601 |
B | HOH706 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGingqLPWsise.DlkfFskiT |
Chain | Residue | Details |
A | GLY18-THR40 |
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrhIltaWNpsalsqma.....LpPCHvlsQYyV |
Chain | Residue | Details |
A | ARG382-VAL410 |