6WEP

Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site

6WEP の概要

• エントリーDOI: 10.2210/pdb6wep/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total)
• 機能のキーワード: ts, ts-dhfr, transferase
• 由来する生物種: Cryptosporidium hominis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122924.76

構造登録者

Czyzyk, D.J.,Ruiz, V.G.,Kumar, V.P.,Jorgensen, W.L.,Anderson, K.S. (登録日: 2020-04-02, 公開日: 2020-06-17, 最終更新日: 2023-10-18)

• 主引用文献: Ruiz, V.G.,Czyzyk, D.J.,Kumar, V.P.,Jorgensen, W.L.,Anderson, K.S.; Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitor; Bioorg.Med.Chem.Lett., 30:127292-127298, 2020; DOI: 10.1016/j.bmcl.2020.127292

実験手法

X-RAY DIFFRACTION (2.79 Å)