6WE2

Human PARP14 (ARTD8), catalytic fragment in complex with RBN012759

Summary for 6WE2

• Entry DOI: 10.2210/pdb6we2/pdb
• Descriptor: Isoform 1 of Protein mono-ADP-ribosyltransferase PARP14, 7-(cyclopropylmethoxy)-5-fluoro-2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}quinazolin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: parp14, artd8, monoparp, adp ribosylation, inhibitor complex, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 44127.06

Authors

Swinger, K.K.,Schenkel, L.B.,Kuntz, K.W. (deposition date: 2020-04-01, release date: 2021-03-24, Last modification date: 2023-10-18)

• Primary citation: Schenkel, L.B.,Molina, J.R.,Swinger, K.K.,Abo, R.,Blackwell, D.J.,Lu, A.Z.,Cheung, A.E.,Church, W.D.,Kunii, K.,Kuplast-Barr, K.G.,Majer, C.R.,Minissale, E.,Mo, J.R.,Niepel, M.,Reik, C.,Ren, Y.,Vasbinder, M.M.,Wigle, T.J.,Richon, V.M.,Keilhack, H.,Kuntz, K.W.; A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.; Cell Chem Biol, 28:1158-, 2021; PubMed: 33705687; DOI: 10.1016/j.chembiol.2021.02.010

Experimental method

X-RAY DIFFRACTION (2.66 Å)